![]() ![]() ![]() Depending on the type of synapse, the post-synaptic neuron The presynaptic neuron is alwaysĪn axon terminal. Have post-synaptic neuron on the other side. It is bound on one side by pre-synaptic neuron and Synaptic cleft is a space between two neurons, connecting them to one another forming a synapse. They include physostigmine, pyridostigmine, neostigmine, etc. These drugs are classified as indirect-acting muscarinic agonists. As a result, they prevent the degradation of acetylcholine. These drugs decrease inhibit the acetylcholine enzyme present in the synaptic cleft. Below is a brief review of some of these diseases. It is now considered that in addition to other factors, alterations in the structure of synapse or synaptic cleft may play an important role in some neurologic and psychiatric conditions. Diseases associated with Synaptic Alterations These drugs are discussedīelow in another heading. They are used in a number of neurologic conditions. ![]() Most of these drugs are the agonists or antagonists of neurotransmitters. Synaptic cleft also acts as a site of action of As a result, the post-junctional neuron is excited to a limited level, preventing its excess excitation. Rapid degradation of excessive neurotransmitters prevents excessive excitation of the post-junctional neurons. This degradation of neurotransmitters regulates the nerve impulse transmission. The neurotransmitters released into the synaptic cleft are much greater than that required to excite the next neuron.Īs mentioned earlier, synaptic cleft harbors enzymes that can degrade neurotransmitters. Synaptic cleft also plays a role in the regulation of nerve impulse transmission. This depletion of neurotransmitters impedes the nerve impulse transmission. They can rapidly degrade the neurotransmitters and decrease their concentration. These enzymes are involved in the degradation of the released neurotransmitters. Synaptic cleft also harbors different enzymes. We will discuss these enzymes in the subsequent This is done by differentĮnzymes present in synaptic cleft. Neurotransmitter concentration to be lowered rapidly. The small size of synaptic cleft also allows the They can act on the post-synaptic neurons and perform their action. The concentration of neurotransmitters immediately rises. This small size of the cleft allows the neurotransmitters to soon pile up in this tiny space. The size of a synaptic cleft is usually of the order of 20nm or 0.02 micrometer. Neurotransmitters can also pile up in the synaptic cleft. Synaptic cleft provides a space to these neurotransmitters to diffuse and act on post-synaptic or post-junctional neurons. When a nerve impulse reaches the axon terminal of a pre-synaptic neuron, it causes degranulation of the vacuoles containing neurotransmitters. These chemicals are called neurotransmitters. Nerve impulses from one neuron to the other, in case of a chemical synapse.Ī chemical synapse is a type of synapse in which nervous signal is transmitted from one neuron to the other through the chemicals that are released in the synaptic cleft. Synaptic cleft is essential for the transmission of ![]()
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